Azapropazone
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azapropazone
An non-steroidal anti-inflammatory drug that is used only for the treatment of rheumatoid arthritis, ankylosing spondylitis (a type of arthritis that affects the spine), and acute gout, but only when these conditions have failed to respond to other non-steroidal anti-inflammatory drugs. It is available as capsules on prescription only.
Side effects:
azapropazone is more likely than other non-steroidal anti-inflammatory drugs to cause severe gastrointestinal bleeding and ulceration. Other side effects include rashes, sensitivity to sunlight (people taking azapropazone should avoid exposure to sunlight or use a sunblock), fluid retention, and (rarely) inflammation of the lungs and blood disorders. See also non-steroidal anti-inflammatory drugs.
Precautions:
azapropazone must not be taken by people with a history of peptic ulcers, inflammatory bowel disease, or blood disorders. See also non-steroidal anti-inflammatory drugs.
Interactions with other drugs:
see non-steroidal anti-inflammatory drugs. In addition:
Clozapine there is an increased risk of agranulocytosis (a blood disorder), and clozapine should not be taken with azapropazone.
Methotrexate should not be taken with azapropazone, as its excretion is reduced by azapropazone, causing amounts of methotrexate to build up and have adverse effects.
Phenytoin should not be taken with azapropazone as its effects are enhanced by azapropazone.
Tolbutamide its effects are enhanced by azapropazone and these two drugs should not be taken together.
Warfarin: should not be taken with azapropazone as its anticoagulant effects are greatly enhanced by azapropazone.
Proprietary preparation:
Rheumox.
| azacitidine, attapulgite, atropine sulphate | |
| azathioprine, azelaic acid, azelastine hydrochloride |
Wikipedia on Answers.com:
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Azapropazone
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| Systematic (IUPAC) name | |
| (RS)-5-dimethylamino-9-methyl-2-prop-2-enylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | POM (UK) |
| Pharmacokinetic data | |
| Half-life | 20 hours |
| Identifiers | |
| CAS number | 13539-59-8  |
| ATC code | M01AX04 |
| PubChem | CID 26098 |
| ChemSpider | 24310  |
| UNII | K2VOT966ZI |
| KEGG | D02966 |
| ChEBI | CHEBI:38010 |
| ChEMBL | CHEMBL1231131 |
| Chemical data | |
| Formula | C16H18N4O2 |
| Mol. mass | 298.33972 g/mol |
| SMILES | eMolecules & PubChem |
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Azapropazone is a non-steroidal anti-inflammatory drug. It is manufacturered by Goldshield under the tradename Rheumox.[1]
It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects.[2] Azopropazone has now been discontinued in the BNF 60 (British National Formulary).
Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized.[3]
References
- ^ http://home.intekom.com/pharm/cont_eth/rheumox.html
- ^ http://www.patient.co.uk/showdoc/30002267/
- ^ Jones CJ (1976). "The pharmacology and pharmacokinetics of azapropazone - a review". Curr Med Res Opin 4 (1): 3–16. doi:10.1185/03007997609109361. PMID 770078.
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