Azilsartan
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Azilsartan
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| Systematic (IUPAC) name | |
| (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-([2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-carboxylate | |
| Clinical data | |
| Trade names | Edarbi |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a611028 |
| Licence data | US FDA:link |
| Pregnancy cat. | C (1st trimester) D (2nd/3rd trimester) (US) |
| Legal status | ℞-only (US) |
| Routes | Oral |
| Identifiers | |
| CAS number | 863031-21-4  |
| ATC code | C09CA09 |
| PubChem | CID 11238823 |
| ChemSpider | 9413866 |
| UNII | F9NUX55P23 |
| Chemical data | |
| Formula | C30H24N4O8 |
| Mol. mass | 568.53 g/mol |
| SMILES | eMolecules & PubChem |
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Azilsartan (INN, codenamed TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension that was developed by Takeda.
It is marketed in tablet form under the trade name Edarbi as the prodrug azilsartan medoxomil (INN, codenamed TAK-491). On 25 February 2011, the U.S. Food and Drug Administration (FDA) approved azilsartan medoxomil for the treatment of high blood pressure in adults.[1] On March 8, 2012, Health Canada approved the drug for mild to moderate essential hypertension. [2]
Mechanism of action
Main article: Angiotensin II receptor antagonist
Azilsartan medoxomil lowers blood pressure by blocking the action of angiotensin II, a vasopressor hormone.
References
- ^ "FDA approves Edarbi to treat high blood pressure" (Press release). U.S. Food and Drug Administration (FDA). February 25, 2011. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm244722.htm. Retrieved 2011-03-01.
- ^ Notice of Decision for EDARBI
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