In population genetics, the Balding–Nichols model is a statistical description of the allele frequencies in the components of a sub-divided population. With background allele frequency p the allele frequencies, F, in sub-populations separated by Wright's FST, are distributed according to independent draws from
where B is the Beta distribution. This distribution has mean p and variance FST p(1 – p).[1]
The model is due to David Balding and Richard Nichols and is widely used in the forensic analysis of DNA profiles and in population models for genetic epidemiology.
Notes
- ^ Price et al. (2006)
References
Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38(8), 904–909. doi:10.1038/ng1847 online
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