Basiliximab
Drug Info:
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Basiliximab
Brand names: Simulect®
- Drug Forms:
- Basiliximab Solution for injection (below)
- Basiliximab injection
Basiliximab Solution for injection
What is this medicine?
BASILIXIMAB (ba sil IK si mab) suppresses the immune system. It is used to prevent organ rejection after a transplant.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•infection
•an unusual or allergic reaction to basiliximab, mouse proteins, mannitol, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
This medicine is for injection or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What may interact with this medicine?
•vaccines
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine.
This medicine may increase your risk of getting an infection. Stay away from people who are sick. See your doctor if you get an infection.
Talk to your doctor if you have surgery within the 12 months of taking this medicine.
This medicine may increase your risk of getting certain kinds of cancer. Talk to your doctor about healthy lifestyle choices, important screenings, and your risk.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing problems
•fever, chills, or other signs of infection
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•constipation
•difficulty sleeping
•headache
•nausea, vomiting
•pain at site where injected
•stomach upset
•tremors
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Oxford A-Z of Medicinal Drugs:
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basiliximab
A monoclonal antibody that prevents proliferation of T lymphocytes (a type of white blood cell). It is used to prevent rejection of kidney transplants (see immunosuppressants). Basiliximab is given by intravenous injection or infusion under specialist supervision and is available on prescription only.
Side effects:
common side effects include constipation, urinary tract infections, nausea, swelling of the ankles, hypertension, anaemia, headache, weight increase, diarrhoea, and upper airways infections.
Precautions:
basiliximab should not be given to women who are pregnant or breastfeeding, and women should use contraception during and for up to 16 weeks after treatment.
Proprietary preparation:
Simulect.
| barrier preparations, barbiturates, bambuterol hydrochloride | |
| becaplermin, beclometasone dipropionate, belladonna extract |
Wikipedia on Answers.com:
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Basiliximab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | CD25 |
| Clinical data | |
| Trade names | Simulect |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | B (US) |
| Legal status | ? |
| Pharmacokinetic data | |
| Half-life | 7.2 days |
| Identifiers | |
| CAS number | 152923-56-3  |
| ATC code | L04AC02 |
| DrugBank | DB00074 |
| UNII | 9927MT646M |
| ChEMBL | CHEMBL1201439  |
| Chemical data | |
| Formula | C6378H9844N1698O1997S48 |
| Mol. mass | 143801.3 g/mol |
 (what is this?) (verify) |
|
Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor [1] of T cells.[2] It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis Pharmaceuticals product[3] and was approved by the Food and Drug Administration (FDA) in 1998.[4]
It is a chimeric CD 25 monoclonal antibody of the IgG1 isotype. It acts as an antagonist at the interleukin-2(IL-2) binding site of the p55 subunit (Tac antigen) of the high affinity IL-2 receptor (CD 25) on the surface of the activated T lymphocytes.
Minimum serum level should be 0.2 ug/ml(ELISA) Dose is 20 mg two times 4 days apart generally in an adult. It is given in two doses, the first within 2 hours of the start of the transplant operation and the second 4 days after the transplant. These saturate the receptors and prevent T cells from replication and also from activating the B cells, which are responsible for the production of antibodies, which would bind to the transplanted organ and stimulate an immune response against the transplant.
Like the similar drug daclizumab, basiliximab reduces the incidence and severity of acute rejection in kidney transplantation without increasing the incidence of opportunistic infections.[citation needed] In the United Kingdom, the National Institute for Health and Clinical Excellence has recommended its use be considered for all kidney transplant recipients.
It has been reported that some cases of Lichen Planus have been successfully treated with Basiliximab as an alternative therapy to Cyclosporine, with a dose of 20 mg every 4 days. No short-term side effects have been reported [5]
References and notes
- ^ Lupo L, Panzera P, Tandoi F, et al. (October 2008). "Basiliximab versus steroids in double therapy immunosuppression in liver transplantation: a prospective randomized clinical trial". Transplantation 86 (7): 925–31. doi:10.1097/TP.0b013e318186b8a3. PMID 18852657. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00007890-200810150-00009.
- ^ IL-2Rα receptor is also known as the CD25 T-cell antigen
- ^ Novartis product page for Simulect (basiliximab for injection) . Retrieved 2005-03-09.
- ^ Waldman, Thomas A. (2003). Immunotherapy: past, present and future. Nature Medicine 9, 269-277.
- ^ A.D. Katsambas, T.M. Lotti European handbook of dermatological treatments 2nd edition, 2003, page 291, ISBN 3-540-00878-0
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Oxford A-Z of Medicinal Drugs
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