Batroxobin
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Batroxobin
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? (US) |
| Identifiers | |
| CAS number | 9039-61-6  |
| ATC code | B02BX03 |
| Chemical data | |
| Formula | ? |
 (what is this?) (verify) |
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Batroxobin is a serine protease[2] derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1.
This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer.[3]. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets[4]
References
- ^ Batroxobin technical sheet
- ^ Lochnit G, Geyer R (March 1995). "Carbohydrate structure analysis of batroxobin, a thrombin-like serine protease from Bothrops moojeni venom". Eur. J. Biochem. 228 (3): 805–16. doi:10.1111/j.1432-1033.1995.tb20326.x. PMID 7737180. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2956&date=1995&volume=228&issue=3&spage=805.
- ^ Technical sheet of Batroxobin from PentaPharm
- ^ Application of snake venom proteins in the diagnosis of hemostatic disorders in 'Medical Use of Snake Venom Proteins, Stocker K, ed. Boca Raton: CRC-Press 1990; 213-52'
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