Bayer can refer to:
- Bayer AG, the German chemical and pharmaceutical company
- Bayer filter, a color filter mosaic also known as a Bayer pattern, used in digital camera image sensors
- Bayer designation for star names
- KFC Uerdingen 05, formally known as FC Bayer 05 Uerdingen, a German football club
- Bayer Leverkusen, a German sports and football club
- Johann Bayer, a German astronomer, who introduced star designation named after him
- Baeyer's reagent, a mild oxidation reagent used in organic chemistry
- Herbert Bayer, an Austrian graphic designer, painter, and photographer
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