Belatacept

Belatacept^?
Therapeutic monoclonal antibody
Source	recombinant
Target	CTLA 4
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Belatacept is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4 [1], which is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids.

It is intended to provide extended graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors.

Immunosuppressants (L04)
Monoclonal antibodies	TNF inhibitors (Infliximab, Adalimumab, Certolizumab pegol), Afelimomab, Anrulizumab, Aselizumab, Atlizumab, Atorolimumab, Azulizumab, Balizumab, Basiliximab, Belimumab, Belizumab, Bertilimumab, Cedelizumab, Citilimumab, Clenoliximab, Daclizumab, Destilimumab, Doraglizumab, Dorlimomab aritox, Dorlixizumab, Dorlizumab, Drinalizumab, Durlizumab, Eculizumab, Efalizumab, Elsilimomab, Erlizumab, Faralimomab, Fontolizumab, Galiximab, Gantenerumab, Gavilimomab, Golimumab, Gomiliximab, Hylizumab, Ibalizumab, Inolimomab, Ipilimumab, Keliximab, Lebrilizumab, Lerdelimumab, Lucalizumab, Lumiliximab, Maslimomab, Mepolizumab, Metelimumab, Morolimumab, Muromonab-CD3, Natalizumab, Nerelimomab, Ocrelizumab, Odulimomab, Omalizumab, Oteliximab, Otelixizumab, Pascolizumab, Pexelizumab, Reslizumab, Rovelizumab, Ruplizumab, Siplizumab, Talizumab, Teglizumab, Telimomab aritox, Teneliximab, Teplizumab, Tilolizumab, Tocilizumab, Toralizumab, Tralizumab, Treglizumab, Trelizumab, Trilizumab, Ubrelizumab, Vapaliximab, Vepalimomab, Visilizumab, Xalizumab, Zanolimumab, Ziralimumab, Zolimomab aritox, Zulizumab
-imus	Abetimus, Difirolimus, Dofosirolimus, Everolimus, Gifosirolimus, Gusperimus, Pimecrolimus, Safosirolimus, Sirolimus, Tacrolimus, Temsirolimus, Torolimus, Zotarolimus
-cept (Fusion protein)	Abatacept, Alefacept, Belatacept, TNF inhibitor (Etanercept)
Other	Anakinra, Azathioprine, Ciclosporin, Leflunomide, Methotrexate, Mycophenolic acid, Thalidomide

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Belatacept

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