Bernadetto de' Medici (died after 1576) was an Italian patrician who moved from Florence to Naples.
A member to a secondary branch of the Medici Family (the one later called of the Princes of Ottaiano), he was the son of Ottaviano de' Medici and Bartolomeo Giugni. In 1559 he married Giulia de' Medici, the illegitimate daughter of Duke Alessandro de' Medici (22 July 1510 - 6 January 1536/37) by Taddea Malespina.
In 1567 he bought the signiory of Ottaiano in the Kingdom of Naples, and moved there, probably due to strife with Grand Duke Cosimo I. He died in Naples after 1576.
His son Alessandro (died 1606) was Lord of Ottaiano and General of the Papal States. His descendants unsuccessfully claimed the title of Grand Duke of Tuscany after the extinction of the main branch of the Medici.
The Medici of Ottaiano are still living.
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