A beta-lactamase inhibitor is a drug given in conjunction with a beta-lactam antibiotic. Although the inhibitor does not usually have significant antibiotic activity on its own,[1] it inhibits activity of beta-lactamase, a protein that confers resistance of beta-lactam antibiotics to bacteria.
Beta-lactamase inhibitors in clinical use include clavulanic acid and its potassium salt (usually combined with amoxicillin or ticarcillin), sulbactam and tazobactam.
References
- ^ "Beta-Lactamase Inhibitors". Department of Nursing of the Fort Hays State University College of Health and Life Sciences. October 2000. http://www.fhsu.edu/nursing/otitis/bl_inhibit.html. Retrieved on 2007-08-17.
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