Big Bertha may refer to:
- Krupp
- Big Bertha (howitzer), a heavy mortar-like howitzer built and used by Germany during World War I, the name being associated with Bertha Krupp, heiress and owner of the Krupp industrial empire.
- Paris Gun, called Big Bertha by the French, and several other big heavy German guns of World War I
- Other
- Big Bertha (golf club), a line of golf clubs from Callaway Golf
- Big Bertha (drum), one of the world's largest bass drums
- MR 0-10-0 Lickey Banker, a large railway banking engine, especially of a 0-10-0 steam locomotive configuration
- Big Bertha (comics), a member of the Great Lakes Avengers in Marvel Comics
- Porsche 917/20, also called Pink Pig
- IBM T220/T221 ECD monitors, nicknamed Big Bertha, LCD monitors with a native resolution of 3840×2400 pixels.
- Big Bertha is the name given to a large artillery cannon in the computer game Total Annihilation.
- Big Bertha (Bomb disposal vehicle) is a police truck used by the NYPD to handle bomb disposals - also called LaGuardia-Pyke Bomb Truck
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