Big Boss may refer to:
- Big Boss (Metal Gear), a fictional character from the Metal Gear video game series.
- The Big Boss, a film starring Bruce Lee
- Big Boss (C.O.P.S.), a fictional character from the toyline C.O.P.S.
- Bigg Boss, the Indian version of the international reality television series Big Brother.
- Big Boss (musician), metal singer from Czech Republic
- Ray Traylor, professional wrestler known as "The Big Boss Man"
- Big Boss, a 1995 Telugu film
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