blastoma

A blastoma is a type of cancer that is caused by malignancies in precursor cells, often called blasts. Examples are nephroblastoma, medulloblastoma and retinoblastoma The suffix blastoma is used to imply a tumor of primitive, incompletely differentiated (or precursor) cells, i.e., chondroblastoma is composed of cells resembling the precursor of chondrocytes.

Blastomas usually occur in children.

Molecular Biology and Treatment

Many types of blastoma have been linked to a mutation in tumor suppressor genes. For example pleuropulmonary blastomas have been linked to a mutation of the coding for p53. However, the mutation which allows proliferation of incompletely differentiated cells can vary from patient to patient and a mutation can alter the prognosis. Thus, in the case of common blastomas, such as retinoblastomas, a practitioner may go directly into treatment, but in the case of rarer, more genetically linked blastomas, practitioners may karyotype the patient before proceeding with treatment.

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