Medical Encyclopedia:
Blood Donation and Registry: Aftercare
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It generally takes about 24 hours for the donor's body to replenish the lost fluid. Replacing the lost red blood cells, however, may take as much as two months. Whole blood donors must wait a minimum of eight weeks before donating again. Some states place further limits on the frequency and/or total number of times an individual may donate blood within a 12-month period.
— Peter Gregutt
