Bubble boy, boy in the bubble and boy in the plastic bubble are colloquialisms used to describe a person who must live in a sterile environment for medical reasons. Notable subjects of this usage are:
- Ted DeVita (1962–1980), a victim of severe aplastic anaemia who was forced to live in a sterile hospital room
- David Vetter (1971–1984), a victim of Severe Combined Immune Deficiency Syndrome who was forced to live in a sterile environment
In popular culture, the terms have been used for:
- The Boy in the Plastic Bubble, a 1976 film starring John Travolta
- "The Boy in the Bubble (song)", a 1986 song by Paul Simon
- "The Bubble Boy (Seinfeld)", a 1992 episode of the Seinfeld TV series
- Bubble Boy, a 2001 film starring Jake Gyllenhaal
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