Butabarbital

Brand names: Butisol®

Chemical formula:

Drug Forms:
• Butabarbital Sodium Oral tablet (below)
• Butabarbital Sodium Oral solution

Espa�ol:
• Butabarbital Sódico, Tableta oral
• Butabarbital Sódico, Solución oral

Butabarbital Sodium Oral tablet

What is this medicine?

BUTABARBITAL (byoo ta BAR bi tal) is a barbiturate. It is used to help you relax for sleep.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•acute or chronic pain
•attempted suicide
•drug abuse or addiction
•if you frequently drink alcohol containing drinks
•liver disease
•lung or breathing disease
•mental depression
•porphyria
•an unusual or allergic reaction to butabarbital, other barbiturates, tartrazine, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
•other barbituates
•voriconazole

This medicine may also interact with the following medications:
•alcohol or medicines that contain alcohol
•antihistamines
•doxycycline
•female hormones, like estrogens or progestins and birth control pills
•griseofulvin
•MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
•medicines for depression, anxiety, or psychotic disturbances
•medicines for sleep
•muscle relaxants
•narcotic medicines for pain
•phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
•steroid medicines like prednisone or cortisone
•warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups.

Do not take this medicine unless you are able to get a full night's sleep before you must be active again. You may not be able to remember things that you do in the hours after you take this medicine. Some people have reported driving, making phone calls, or preparing and eating food while asleep after taking sleep medicine. Take this medicine right before going to sleep. Tell your doctor if you are have any problems with your memory.

If you have been taking this medicine for a long time, do not suddenly stop taking it because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•agitation, confusion, irritability
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing problems
•changes in vision
•feeling faint, lightheaded
•fever
•hallucinations
•low blood pressure
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•unusual activities while asleep like driving, eating, making phone calls
•unusual bleeding, bruising
•unusually weak or tired
•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•constipation
•dizziness
•drowsiness
•headache
•nausea, vomiting
•nightmares, trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Butabarbital

Systematic (IUPAC) name
5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione
Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682417
Pregnancy cat.	?
Legal status	Schedule III (CA) Schedule III (US)
Pharmacokinetic data
Half-life	100 hours [1]
Identifiers
CAS number	125-40-6
ATC code	None
PubChem	CID 2479
DrugBank	DB00237
ChemSpider	2385 Y
UNII	P0078O25A9 Y
KEGG	D03180 Y
ChEBI	CHEBI:3228 Y
ChEMBL	CHEMBL449 Y
Synonyms	Butabarbital, Butisol
Chemical data
Formula	C10H16N2O3
Mol. mass	212.246 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15) Y Key:ZRIHAIZYIMGOAB-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its intermediate duration of action gives butabarbital an abuse potential slightly lower than secobarbital.

Butabarbital is also sold in combination with belladonna alkaloids under the brand name Butibel. The belladonna is added for antispasmodic effect. This product contains a low dose of butabarbital combined with a standardised mix of belladonna alkaloids and is used as an antispasmodic taken to relieve cramping and spasms of the stomach and intestines. They are used also to decrease the amount of acid formed in the stomach. Another similar product is Donnatal, which contains belladonna alkaloids combined with phenobarbital.

References

1. ^ http://www.rxlist.com/butisol-drug.html

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