C-fos induced growth factor: Information from Answers.com

C-fos induced growth factor (vascular endothelial growth factor D)

Identifiers

FIGF; VEGF-D; VEGFD

External IDs

OMIM: 300091 MGI: 108037 HomoloGene: 3288

Gene ontology
Molecular function	• platelet-derived growth factor receptor binding • growth factor activity
Cellular component	• extracellular region • extracellular space • membrane
Biological process	• regulation of progression through cell cycle • angiogenesis • multicellular organismal development • cell proliferation • positive regulation of cell proliferation • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq

NM_004469 (mRNA)

XM_988606 (mRNA)

NP_004460 (protein)

XP_993700 (protein)

Location

Chr X:
15.27 - 15.31 Mb

Chr X:
159.72 - 159.75 Mb

PubMed search

[1]

[2]

C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D) is a vascular endothelial growth factor. FIGF is also its human gene.^[1]

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.^[1]

References

^ ^a ^b "Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2277.

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Orlandini M, Marconcini L, Ferruzzi R, Oliviero S (1996). "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family.". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11675–80. doi:10.1073/pnas.93.21.11675. PMID 8876195.
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Rocchigiani M, Lestingi M, Luddi A et al. (1998). "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes.". Genomics 47 (2): 207–16. doi:10.1006/geno.1997.5079. PMID 9479493.
Stacker SA, Stenvers K, Caesar C et al. (1999). "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.". J. Biol. Chem. 274 (45): 32127–36. doi:10.1074/jbc.274.45.32127. PMID 10542248.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakamura Y, Yasuoka H, Tsujimoto M et al. (2003). "Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up.". Clin. Cancer Res. 9 (2): 716–21. PMID 12576440.
Yokoyama Y, Charnock-Jones DS, Licence D et al. (2003). "Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma.". Br. J. Cancer 88 (2): 237–44. doi:10.1038/sj.bjc.6600701. PMID 12610509.
Rissanen TT, Markkanen JE, Gruchala M et al. (2003). "VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.". Circ. Res. 92 (10): 1098–106. doi:10.1161/01.RES.0000073584.46059.E3. PMID 12714562.
Funaki H, Nishimura G, Harada S et al. (2003). "Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma.". Oncology 64 (4): 416–22. doi:10.1159/000070301. PMID 12759540.
Orlandini M, Semboloni S, Oliviero S (2004). "Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability.". J. Biol. Chem. 278 (45): 44650–6. doi:10.1074/jbc.M304255200. PMID 12920128.
McColl BK, Baldwin ME, Roufail S et al. (2003). "Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.". J. Exp. Med. 198 (6): 863–8. doi:10.1084/jem.20030361. PMID 12963694.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Vlahakis NE, Young BA, Atakilit A, Sheppard D (2005). "The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.". J. Biol. Chem. 280 (6): 4544–52. doi:10.1074/jbc.M412816200. PMID 15590642.
Kurahara H, Takao S, Maemura K et al. (2005). "Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis.". Clin. Cancer Res. 10 (24): 8413–20. doi:10.1158/1078-0432.CCR-04-0379. PMID 15623620.
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Kaushal V, Mukunyadzi P, Dennis RA et al. (2005). "Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease.". Clin. Cancer Res. 11 (2 Pt 1): 584–93. PMID 15701844.
Yasuoka H, Nakamura Y, Zuo H et al. (2005). "VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma.". Mod. Pathol. 18 (8): 1127–33. doi:10.1038/modpathol.3800402. PMID 15803188.

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v • d • e Growth factors

Fibroblast	FGF receptor ligands: 1 (acidic)/2 (basic)/5 · 3/4/6 · KGF (7/10/22) · 8/17/18 · 9/16/20 FGF homologous factors: 11 · 12 · 13 · 14 hormone-like: 19 · 21 · 23

EGF-like domain	TGFα · Epidermal · Heparin-binding EGF-like

TGFβ pathway	TGFβ (1, 2, 3)

Insulin-like	1 · 2

Platelet-derived	A · B · C · D

Vascular endothelial	A · B · C · D · PGF

Other	Nerve · Hepatocyte

see also growth factor receptors

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C-fos induced growth factor

References

Further reading