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complement component 4 binding protein, alpha
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| Identifiers | |
| Symbol | C4BPA |
| Alt. Symbols | C4BP |
| Entrez | 722 |
| HUGO | 1325 |
| OMIM | 120830 |
| RefSeq | NM_000715 |
| UniProt | P04003 |
| Other data | |
| Locus | Chr. 1 q32 |
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complement component 4 binding protein, beta
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| Identifiers | |
| Symbol | C4BPB |
| Alt. Symbols | C4BP |
| Entrez | 725 |
| HUGO | 1328 |
| OMIM | 120831 |
| RefSeq | NM_000716 |
| UniProt | P20851 |
| Other data | |
| Locus | Chr. 1 q32 |
C4BP is a protein involved in the complement system. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains.
Functions
It inhibits the action of C4, more specifically the classical pathway. It splits C4 convertase and is a cofactor for factor I which cleaves C4b.
C4BP binds necrotic cells and DNA, to clean up after swelling.
It also binds CD40 on B cells which potentiaties proliferation and costimulation.
External links
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