A calcium ion binding protein effecting a sequestration of calcium ions within the smooth endoplasmic reticulum.
Calsequestrin
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| Calsequestrin monomer showing the three repeating calsequestrin domains | |
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calsequestrin 1 (fast-twitch, skeletal muscle)
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| Identifiers | |
| Symbol | CASQ1 |
| Alt. Symbols | CASQ |
| Entrez | 844 |
| HUGO | 1512 |
| OMIM | 114250 |
| PDB | 1A8Y |
| RefSeq | NM_001231 |
| UniProt | P31415 |
| Other data | |
| Locus | Chr. 1 q21 |
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calsequestrin 2 (cardiac muscle)
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| Identifiers | |
| Symbol | CASQ2 |
| Entrez | 845 |
| HUGO | 1513 |
| OMIM | 114251 |
| RefSeq | NM_001232 |
| UniProt | O14958 |
| Other data | |
| Locus | Chr. 1 p13.3-p11 |
Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps sarcoplasmic reticulum store an amazing amount of calcium ions.
See also
External links
References
Wang S, Trumble WR, Liao H, Wesson CR, Dunker AK, Kang CH (1998). "Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum". Nat. Struct. Biol. 5 (6): 476–83. doi:. PMID 9628486.
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The principle calcium - binding protein found in the Sarcoplasmic Reticulum which also provides calcium storage
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Calsequestrin". Read more |
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