Carbamoyl phosphate

Carbamoyl phosphate
Identifiers
CAS number	590-55-6
PubChem	278
MeSH	Carbamoyl+phosphate
SMILES	C(=O)(N)OP(=O)(O)O
Properties
Molecular formula	CH4NO5P
Molar mass	141.020 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.

It is produced from bicarbonate, ammonia, and phosphate, the latter derived from ATP. The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

• HCO₃⁻ + ATP → ADP + HO–C(O)–OPO₃²⁻ (carbonyl phosphate)
• HO–C(O)–OPO₃²⁻ + NH₃ + OH⁻ → HPO₄²⁻ + ⁻O–C(O)NH₂ + H₂O
• ⁻O–C(O)NH₂ + ATP → ADP + H₂NC(O)OPO₃²⁻

See also

• Ornithine transcarbamylase

References

• Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York. 

v • d • e Urea cycle Metabolic Pathway
L-citrulline Carbamoyl phosphate L-ornithine Pi L-aspartate Urea + ATP PPi + AMP H2O L-argininosuccinate Fumarate L-arginine see also enzymes, disorders