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| Systematic (IUPAC) name | |
|---|---|
| (5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-15- methylprosta-5,13-dien-1-oic acid | |
| Identifiers | |
| CAS number | 58551-69-2 |
| ATC code | G02AD04 |
| PubChem | 5284525 |
| DrugBank | APRD00847 |
| ChemSpider | 4447583 |
| Chemical data | |
| Formula | C21H36O5 |
| Mol. mass | 368.508 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | Intravenous |
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Carboprost is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α) with oxytocic properties. The trade name of carboprost tromethamine is Hemabate.
Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding. It is used for the treatment of molar pregnancy.
Exert caution in asthmatic patients.
External links
- MeSH Carboprost
- Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas.". J Am Assoc Gynecol Laparosc 11 (1): 68–72. doi:. PMID 15104835.
- Vukelić J. "Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine.". Med Pregl 54 (1-2): 11–6. PMID 11436877.
- Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation.". Urology 46 (6): 811–5. doi:. PMID 7502421.
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