| Carboxyglutamic acid | |
|---|---|
 |
|
| IUPAC name |
3-Aminopropane-1,1,3-tricarboxylic acid
|
| Other names | γ-Carboxyglutamate |
| Identifiers | |
| CAS number | 53445-96-8 |
| PubChem | 40772 |
| SMILES |
C(C(C(=O)O)C(=O)O)C(C(=O)O)N
|
| Properties | |
| Molecular formula | C6H9NO6 |
| Molar mass | 191.14 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Carboxyglutamic acid (or the conjugate base, carboxyglutamate) is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, Vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, and X.
See also
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