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Carmofur
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| Systematic (IUPAC) name | |
| 5-fluoro-N-hexyl-2,4-dioxo-pyrimidine-1-carboxamide | |
| Identifiers | |
| CAS number | |
| ATC code | L01 |
| PubChem | |
| Chemical data | |
| Formula | C11H16FN3O3 |
| Mol. mass | 257.261 g/mol |
| SMILES | & |
| Synonyms | 1-hexylcarbamoyl-5-fluorouracil |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.
Contents |
Mechanism of action
Uses
Breast Cancer
Colorectal Cancer
Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.[1]
Adverse effects
As fluorouracil, carmofur has been known to induce leukoencephalopathy.[2][3][4]
References
- ^ Junichi S, et al.. Japanese Journal of Clinical Oncology Advance Access originally published online on September 9, 2005 Japanese Journal of Clinical Oncology 2005 35(9):536-544. doi:.
- ^ Yamada T, Okamura S, Okazaki T, et al. (June 1989). "Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature". Asia Oceania J Obstet Gynaecol 15 (2): 161–8. PMID 2667512.
- ^ Mizutani T (February 2008). "[Leukoencephalopathy caused by antineoplastic drugs]" (in Japanese). Brain Nerve 60 (2): 137–41. PMID 18306661.
- ^ Baehring JM, Fulbright RK (May 2008). "Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients". J Neurol Neurosurg Psychiatr 79 (5): 535–9. doi:. PMID 17682013.
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