Caspase 7: Information from Answers.com

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Caspase 7, apoptosis-related cysteine peptidase

PDB rendering based on 1f1j.

Available structures

1f1j, 1gqf, 1i4o, 1i51, 1k86, 1k88, 1kmc, 1shj, 1shl

Identifiers

Symbols

CASP7; CMH-1; ICE-LAP3; MCH3

External IDs

OMIM: 601761 MGI: 109383 HomoloGene: 11168

Gene ontology
Molecular function	• protein binding • peptidase activity • cysteine-type peptidase activity • caspase activity
Cellular component	• cytoplasm • endoplasmic reticulum membrane • mitochondrial membrane
Biological process	• release of cytochrome c from mitochondria • proteolysis • heart development • apoptotic program • response to UV

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq

NM_001227 (mRNA)

NM_007611 (mRNA)

NP_001218 (protein)

NP_031637 (protein)

Location

Chr 10:
115.43 - 115.48 Mb

Chr 19:
56.46 - 56.49 Mb

PubMed search

[1]

[2]

Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein and gene.

Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing by upstream caspases (caspase-8, -9)at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.^[1]

1 Interactions
2 References
3 See also
4 Further reading

Interactions

Caspase 7 has been shown to interact with Caspase 8,^[2]^[3] Survivin^[4]^[5] and XIAP.^[6]^[7]^[8]^[9]

References

^ "Entrez Gene: CASP7 caspase 7, apoptosis-related cysteine peptidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=840.
^ Guo, Yin; Srinivasula Srinivasa M, Druilhe Anne, Fernandes-Alnemri Teresa, Alnemri Emad S (Apr. 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. (United States) 277 (16): 13430-7. doi:10.1074/jbc.M108029200. ISSN 0021-9258. PMID 11832478.
^ Srinivasula, S M; Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri E S (Dec. 1996). "Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (25): 14486-91. ISSN 0027-8424. PMID 8962078.
^ Tamm, I; Wang Y, Sausville E, Scudiero D A, Vigna N, Oltersdorf T, Reed J C (Dec. 1998). "IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs". Cancer Res. (UNITED STATES) 58 (23): 5315-20. ISSN 0008-5472. PMID 9850056.
^ Shin, S; Sung B J, Cho Y S, Kim H J, Ha N C, Hwang J I, Chung C W, Jung Y K, Oh B H (Jan. 2001). "An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7". Biochemistry (United States) 40 (4): 1117-23. ISSN 0006-2960. PMID 11170436.
^ Riedl, S J; Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik S W, Liddington R C, Salvesen G S (Mar. 2001). "Structural basis for the inhibition of caspase-3 by XIAP". Cell (United States) 104 (5): 791-800. ISSN 0092-8674. PMID 11257232.
^ Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (Dec. 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914-25. doi:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMID 9384571.
^ Deveraux, Q L; Takahashi R, Salvesen G S, Reed J C (Jul. 1997). "X-linked IAP is a direct inhibitor of cell-death proteases". Nature (ENGLAND) 388 (6639): 300-4. doi:10.1038/40901. ISSN 0028-0836. PMID 9230442.
^ Suzuki, Y; Nakabayashi Y, Nakata K, Reed J C, Takahashi R (Jul. 2001). "X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes". J. Biol. Chem. (United States) 276 (29): 27058-63. doi:10.1074/jbc.M102415200. ISSN 0021-9258. PMID 11359776.

v • d • e Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 · Caspase 2 · Caspase 3 · Caspase 4 · Caspase 5 · Caspase 6 · Caspase 7 · Caspase 8 · Caspase 9 · Caspase 10 · Caspase 12 · Caspase 13 · Caspase 14

Fruit-derived	Papain · Ficain · Bromelain · Actinidain

Calpain	CAPN1 · CAPN2 · CAPN3 · CAPN5 · CAPN6 · CAPN7 · CAPN8 · CAPN9 · CAPN10 · CAPN11 · CAPN12 · CAPN13 · CAPN14 · CAPNS1 · CAPNS2

Cathepsin	B · C · F · H · K · L1/L2 · O · S · W · Z

Other	Clostripain · Cancer procoagulant · Separase · Autophagin · Cruzipain

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Caspase 7

Contents

Interactions

References

See also

Further reading