CBD is a common abbreviation for a central business district. It may also refer to:
- Brazilian Sport Confederation, from 1919 to 1979 predecessor of Brazilian Football Confederation, the national governing body for soccer in Brazil
- Cannabidiol, a major cannabinoid found in cannabis
- Cash Before Delivery, a credit term
- Car Nicobar Air Force Base, the IATA code for the airport in India
- CBD-FM, a CBC Radio One station in Saint John, Canada
- CBD Media, the directory publishing and advertising division of Cincinnati Bell
- Cecil B. DeMille, film director and Academy Award-winning film producer
- Cellulose binding domain
- Central business district, the commercial and often geographic heart of a city
- Chemical Bath Deposition, a technique used to deposit thin films onto surfaces
- Christian Book Distributors
- Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract
- Community Based Distribution
- Companhia Brasileira de Distribuição (doing business as Grupo Pão de Açúcar)
- Component-based development in software engineering
- Convention on Biological Diversity, an international legally binding treaty
- Customer and Deposit System Development
- Chronic Bitch Dependency, a reference to the show The Boondocks on Adult Swim
- Gaborone central business district, a new area of development in Gaborone
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