CCL3

Chemokine (C-C motif) ligand 3
PDB rendering based on 1b50.
Available structures
1b50, 1b53
Identifiers
Symbols	CCL3; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs	OMIM: 182283 HomoloGene: 88430
Gene ontology Molecular function • signal transducer activity • chemokine activity • chemoattractant activity Cellular component • extracellular region • extracellular space • soluble fraction Biological process • cellular calcium ion homeostasis • exocytosis • cell motility • chemotaxis • inflammatory response • immune response • cytoskeleton organization and biogenesis • signal transduction • G-protein coupled receptor protein signaling pathway • cell-cell signaling • antimicrobial humoral response • regulation of viral genome replication
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6348	n/a
Ensembl	ENSG00000006075	n/a
UniProt	P10147	n/a
RefSeq	NM_002983 (mRNA)	n/a (mRNA)
	NP_002974 (protein)	n/a (protein)
Location	Chr 17: 31.44 - 31.44 Mb	n/a
PubMed search	[1]	n/a

C-C motif chemokine 3 is a protein that in humans is encoded by the CCL3 gene.

Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM]^[1]

Interactions

CCL3 has been shown to interact with CCL4.^[2]

See also

• Macrophage inflammatory proteins

References

Further reading

v • d • e PDB Gallery 1b50: NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES   1b53: NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it. v • d • e