CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 is a carbohydrate[1] adhesion molecule (not a protein) that can be expressed on glycoproteins, glycolipids and proteoglycans.
Function
CD15 mediates phagocytosis and chemotaxis, found on neutrophils;[2] expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage specific embryonic
See also
References
- ^ MeSH CD15+Antigen
- ^ Kerr MA, Stocks SC (November 1992). "The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion". Histochem. J. 24 (11): 811–26. PMID 1362195.
- ^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:. PMID 11278338.
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