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CD151 molecule (Raph blood group)
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| Identifiers | ||||||||||||||
| Symbols | CD151; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24 | |||||||||||||
| External IDs | OMIM: 602243 MGI: 1096360 HomoloGene: 20916 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 977 | 12476 | ||||||||||||
| Ensembl | ENSG00000177697 | ENSMUSG00000025510 | ||||||||||||
| Uniprot | P48509 | Q921J7 | ||||||||||||
| Refseq | NM_001039490 (mRNA) NP_001034579 (protein) |
NM_009842 (mRNA) NP_033972 (protein) |
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| Location | Chr 11: 0.82 - 0.83 Mb | Chr 7: 141.32 - 141.32 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1]
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See also
Interactions
CD151 has been shown to interact with CD46.[2]
References
- ^ a b "Entrez Gene: CD151 CD151 molecule (Raph blood group)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977.
- ^ Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar. 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. (GERMANY) 30 (3): 900-7. doi:. ISSN 0014-2980. PMID 10741407.
Further reading
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Ashman LK (2003). "CD151.". J. Biol. Regul. Homeost. Agents 16 (3): 223–6. PMID 12456024.
- Ashman LK, Aylett GW, Mehrabani PA, et al. (1992). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen.". Br. J. Haematol. 79 (2): 263–70. doi:. PMID 1958484.
- Fitter S, Tetaz TJ, Berndt MC, Ashman LK (1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.". Blood 86 (4): 1348–55. PMID 7632941.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Hasegawa H, Utsunomiya Y, Kishimoto K, et al. (1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily.". J. Virol. 70 (5): 3258–63. PMID 8627808.
- Hasegawa H, Kishimoto K, Yanagisawa K, et al. (1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization.". Genomics 40 (1): 193–6. doi:. PMID 9070943.
- Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin.". J. Histochem. Cytochem. 45 (4): 515–25. PMID 9111230.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:. PMID 9373149.
- Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms.". Biochim. Biophys. Acta 1398 (1): 75–85. PMID 9602068.
- Sincock PM, Fitter S, Parton RG, et al. (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.". J. Cell. Sci. 112 ( Pt 6): 833–44. PMID 10036233.
- Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 ( Pt 1): 103–11. doi:. PMID 10229664.
- Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis.". Cancer Res. 59 (15): 3812–20. PMID 10447000.
- Sterk LM, Geuijen CA, Oomen LC, et al. (2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.". J. Cell Biol. 149 (4): 969–82. doi:. PMID 10811835.
- Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.". Biochem. Biophys. Res. Commun. 281 (2): 425–30. doi:. PMID 11181065.
- Charrin S, Le Naour F, Oualid M, et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.". J. Biol. Chem. 276 (17): 14329–37. doi:. PMID 11278880.
- Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:. PMID 11337467.
- Kohno M, Hasegawa H, Miyake M, et al. (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase.". Int. J. Cancer 97 (3): 336–43. doi:. PMID 11774285.
- Zhang XA, Kazarov AR, Yang X, et al. (2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.". Mol. Biol. Cell 13 (1): 1–11. doi:. PMID 11809818.
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