CD20

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.

Function

The protein has no known natural ligand and its function is unclear. It is suspected that it acts as a calcium channel in the cell membrane. It is also found on B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia.

Clinical significance

It is the target of the monoclonal antibodies rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias.

FMC7 appears to be a conformational variant.^[1]

References

1. ^ Polyak MJ, Ayer LM, Szczepek AJ, Deans JP (2003). "A cholesterol-dependent CD20 epitope detected by the FMC7 antibody". Leukemia 17 (7): 1384-9. DOI:10.1038/sj.leu.2402978. PMID 12835728. 

External links

• MeSH CD20+antigen

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