CD247

CD247 molecule
PDB rendering based on 2hac.
Available structures: 2hac
Identifiers
Symbols	CD247; CD3-ZETA; CD3H; CD3Q; CD3Z; TCRZ
External IDs	OMIM: 186780 MGI: 88334 HomoloGene: 12818
Gene ontology Molecular function: • transmembrane receptor activity • receptor signaling protein activity • protein homodimerization activity Cellular component: • cytoplasm • plasma membrane • membrane • integral to membrane • T cell receptor complex Biological process: • cell surface receptor linked signal transduction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	919	12503
Ensembl	ENSG00000198821	ENSMUSG00000005763
Uniprot	P20963	P29020
Refseq	NM_000734 (mRNA) NP_000725 (protein)	NM_031162 (mRNA) NP_112439 (protein)
Location	Chr 1: 165.67 - 165.75 Mb	Chr 1: 167.63 - 167.71 Mb
Pubmed search	[1]	[2]

CD247 (Cluster of Differentiation 247) is a human protein encoded by the CD247 gene.

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

See also

• Cluster of differentiation

Interactions

CD247 has been shown to interact with Janus kinase 3^[2] and Protein unc-119 homolog.^[3]

References

Further reading

v • d • e PDB Gallery 2hac: Structure of Zeta-Zeta Transmembrane Dimer

External links

• MeSH CD247+protein,+human

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