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CD27 is a tumor necrosis factor receptor.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.[1]
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Interactions
CD27 has been shown to interact with SIVA1,[2] TRAF2[3][4] and TRAF3.[3][4]
References
- ^ "Entrez Gene: CD27 CD27 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=939.
- ^ Prasad, K V; Ao Z, Yoon Y, Wu M X, Rizk M, Jacquot S, Schlossman S F (Jun. 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (12): 6346-51. ISSN 0027-8424. PMID 9177220.
- ^ a b Yamamoto, H; Kishimoto T, Minamoto S (Nov. 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753-9. ISSN 0022-1767. PMID 9794406.
- ^ a b Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May. 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353-8. ISSN 0021-9258. PMID 9582383.
Further reading
- Lens SM, de Jong R, Hintzen RQ, et al. (1996). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.". Leuk. Lymphoma 18 (1-2): 51–9. PMID 8580829.
- Agematsu K (2000). "Memory B cells and CD27.". Histol. Histopathol. 15 (2): 573–6. PMID 10809378.
- van Baarle D, Kostense S, van Oers MH, et al. (2003). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue.". Trends Immunol. 23 (12): 586–91. doi:. PMID 12464570.
- Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus.". Lupus 13 (5): 283–9. doi:. PMID 15230280.
External links
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