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CD7 molecule
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| Identifiers | ||||||||||||||
| Symbols | CD7; GP40; LEU-9; TP41; Tp40 | |||||||||||||
| External IDs | OMIM: 186820 MGI: 88344 HomoloGene: 4471 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 924 | 12516 | ||||||||||||
| Ensembl | ENSG00000173762 | ENSMUSG00000025163 | ||||||||||||
| Uniprot | P09564 | Q3U4A8 | ||||||||||||
| Refseq | NM_006137 (mRNA) NP_006128 (protein) |
NM_009854 (mRNA) NP_033984 (protein) |
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| Location | Chr 17: 77.87 - 77.87 Mb | Chr 11: 120.85 - 120.86 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD7 (Cluster of Differentiation 7) is a human protein encoded by the CD7 gene.[1]
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]
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See also
Interactions
CD7 has been shown to interact with PIK3R1.[2][3]
References
- ^ a b "Entrez Gene: CD7 CD7 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=924.
- ^ Lee, D M; Patel D D, Pendergast A M, Haynes B F (Aug. 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. (ENGLAND) 8 (8): 1195-203. ISSN 0953-8178. PMID 8918688.
- ^ Subrahmanyam, Gosukonda; Rudd Christopher E, Schneider Helga (Jan. 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. (Germany) 33 (1): 46-52. doi:. ISSN 0014-2980. PMID 12594831.
Further reading
- Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation.". Immunol. Res. 24 (1): 31–52. doi:. PMID 11485208.
- Baker E, Sandrin MS, Garson OM, et al. (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization.". Immunogenetics 31 (5-6): 412–3. doi:. PMID 1695199.
- Schanberg LE, Fleenor DE, Kurtzberg J, et al. (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603–7. doi:. PMID 1703303.
- Yoshikawa K, Seto M, Ueda R, et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.". Immunogenetics 33 (5-6): 352–60. doi:. PMID 1711009.
- Ware RE, Scearce RM, Dietz MA, et al. (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.". J. Immunol. 143 (11): 3632–40. PMID 2479685.
- Osada S, Utsumi KR, Ueda R, et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.". Cytogenet. Cell Genet. 47 (1-2): 8–10. doi:. PMID 3258561.
- Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.". Embo J. 6 (11): 3313–6. PMID 3501369.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:. PMID 8125298.
- Lee DM, Schanberg LE, Fleenor DE, et al. (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.". Immunogenetics 44 (2): 108–14. PMID 8662072.
- Bevec T, Stoka V, Pungercic G, et al. (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331–8. doi:. PMID 8666891.
- Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7.". Cell. Immunol. 173 (1): 15–21. doi:. PMID 8871597.
- Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.". Int. Immunol. 8 (8): 1195–203. doi:. PMID 8918688.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:. PMID 9373149.
- Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327–40. doi:. PMID 9480746.
- Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171–9. doi:. PMID 9852078.
- Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801–11. PMID 10490978.
- Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431–7. doi:. PMID 10652336.
- Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:. PMID 11423532.
- Rossi MI, Yokota T, Medina KL, et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes.". Blood 101 (2): 576–84. doi:. PMID 12393702.
External links
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