CD86

CD86 molecule
PDB rendering based on 1i85.
Available structures
1i85, 1ncn
Identifiers
Symbols	CD86; B7-2; B70; CD28LG2; LAB72; MGC34413
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443
Gene ontology Molecular function • protein binding • coreceptor activity • transcription activator activity Cellular component • plasma membrane • external side of plasma membrane • integral to membrane Biological process • immune response • cell-cell signaling • positive regulation of cell proliferation • T cell activation • positive regulation of lymphotoxin A biosynthetic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of interleukin-4 biosynthetic process • positive regulation of T-helper 2 cell differentiation • positive regulation of transcription
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	942	12524
Ensembl	ENSG00000114013	ENSMUSG00000022901
UniProt	P42081	Q3T9F8
RefSeq	NM_006889 (mRNA)	NM_019388 (mRNA)
	NP_008820 (protein)	NP_062261 (protein)
Location	Chr 3: 123.26 - 123.32 Mb	Chr 16: 36.52 - 36.59 Mb
PubMed search	[1]	[2]

The protein CD86 (Cluster of Differentiation 86) is a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation and survival. It is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). CD86 is also known as B7.2. Its principal mode of action is by binding to CD28. Along with CD80, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[1]

See also

• Cluster of differentiation

References

v • d • e PDB Gallery 1i85: CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX   1ncn: the receptor-binding domain of human B7-2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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