Cadherin 2, type 1, N-cadherin (neuronal), also known as CDH2, is a protein which in humans is encoded by the CDH2 gene.[1][2] CDH2 has also been designated as CD325 (cluster of differentiation 325).
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.[3]
Interactions
CDH2 has been shown to interact with Beta-catenin,[4][5] Plakoglobin,[4][6] Catenin (cadherin-associated protein), alpha 1,[4][5] CTNND1,[4][5] LRRC7[7] and CDH11.[4]
References
- ^ Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N, Goodfellow PN (September 1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene". J. Neurochem. 55 (3): 805–12. doi:10.1111/j.1471-4159.1990.tb04563.x. PMID 2384753.
- ^ Reid RA, Hemperly JJ (October 1990). "Human N-cadherin: nucleotide and deduced amino acid sequence". Nucleic Acids Res. 18 (19): 5896. doi:10.1093/nar/18.19.5896. PMID 2216790.
- ^ "Entrez Gene: CDH2 cadherin 2, type 1, N-cadherin (neuronal)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1000.
- ^ a b c d e Straub, Beate K; Boda Judit, Kuhn Caecilia, Schnoelzer Martina, Korf Ulrike, Kempf Tore, Spring Herbert, Hatzfeld Mechthild, Franke Werner W (Dec. 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392.
- ^ a b c Wahl, James K; Kim Young J, Cullen Janet M, Johnson Keith R, Wheelock Margaret J (May. 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. (United States) 278 (19): 17269–76. doi:10.1074/jbc.M211452200. ISSN 0021-9258. PMID 12604612.
- ^ Sacco, P A; McGranahan T M, Wheelock M J, Johnson K R (Aug. 1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin". J. Biol. Chem. (UNITED STATES) 270 (34): 20201–6. ISSN 0021-9258. PMID 7650039.
- ^ Izawa, Ichiro; Nishizawa Miwako, Ohtakara Kazuhiro, Inagaki Masaki (Feb. 2002). "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. (United States) 277 (7): 5345–50. doi:10.1074/jbc.M110052200. ISSN 0021-9258. PMID 11729199.
Further reading
- Doherty P, Smith P, Walsh FS (1997). "Shared cell adhesion molecule (CAM) homology domains point to CAMs signalling via FGF receptors.". Perspectives on developmental neurobiology 4 (2-3): 157–68. PMID 9168198.
- Makrigiannakis A, Coukos G, Blaschuk O, Coutifaris C (2000). "Follicular atresia and luteolysis. Evidence of a role for N-cadherin.". Ann. N. Y. Acad. Sci. 900: 46–55. PMID 10818391.
- Hazan RB, Qiao R, Keren R, et al. (2004). "Cadherin switch in tumor progression.". Ann. N. Y. Acad. Sci. 1014: 155–63. doi:10.1196/annals.1294.016. PMID 15153430.
- Cavallaro U (2005). "N-cadherin as an invasion promoter: a novel target for antitumor therapy?". Current opinion in investigational drugs (London, England : 2000) 5 (12): 1274–8. PMID 15648948.
- Salomon D, Ayalon O, Patel-King R, et al. (1992). "Extrajunctional distribution of N-cadherin in cultured human endothelial cells.". J. Cell. Sci. 102 ( Pt 1): 7–17. PMID 1500442.
- Knudsen KA, Wheelock MJ (1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.". J. Cell Biol. 118 (3): 671–9. doi:10.1083/jcb.118.3.671. PMID 1639850.
- Reid RA, Hemperly JJ (1990). "Human N-cadherin: nucleotide and deduced amino acid sequence.". Nucleic Acids Res. 18 (19): 5896. doi:10.1093/nar/18.19.5896. PMID 2216790.
- Walsh FS, Barton CH, Putt W, et al. (1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.". J. Neurochem. 55 (3): 805–12. doi:10.1111/j.1471-4159.1990.tb04563.x. PMID 2384753.
- Selig S, Bruno S, Scharf JM, et al. (1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (9): 3702–6. doi:10.1073/pnas.92.9.3702. PMID 7731968.
- Wallis J, Fox MF, Walsh FS (1994). "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2.". Genomics 22 (1): 172–9. doi:10.1006/geno.1994.1358. PMID 7959764.
- Andersson AM, Edvardsen K, Skakkebaek NE (1995). "Expression and localization of N- and E-cadherin in the human testis and epididymis.". Int. J. Androl. 17 (4): 174–80. doi:10.1111/j.1365-2605.1994.tb01239.x. PMID 7995652.
- Matsuyoshi N, Imamura S (1997). "Multiple cadherins are expressed in human fibroblasts.". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
- Navarro P, Ruco L, Dejana E (1998). "Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization.". J. Cell Biol. 140 (6): 1475–84. doi:10.1083/jcb.140.6.1475. PMID 9508779.
- Gaidar YA, Lepekhin EA, Sheichetova GA, Witt M (1998). "Distribution of N-cadherin and NCAM in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system.". Acta Histochem. 100 (1): 83–97. PMID 9542583.
- Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
- Lu Q, Paredes M, Medina M, et al. (1999). "delta-catenin, an adhesive junction-associated protein which promotes cell scattering.". J. Cell Biol. 144 (3): 519–32. doi:10.1083/jcb.144.3.519. PMID 9971746.
- Shan WS, Tanaka H, Phillips GR, et al. (2000). "Functional cis-heterodimers of N- and R-cadherins.". J. Cell Biol. 148 (3): 579–90. doi:10.1083/jcb.148.3.579. PMID 10662782.
- Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
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PDB Gallery |
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1ncg: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
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1nch: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
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1nci: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
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1ncj: N-CADHERIN, TWO-DOMAIN FRAGMENT
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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