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Cefpodoxime

 
Drug Info: Cefpodoxime

Brand names: Banan®Vantin®

Chemical formula:



Cefpodoxime oral suspension

What is cefpodoxime oral suspension?

CEFPODOXIME (Vantin®) is a cephalosporin antibiotic. It treats many kinds of infections, including those of the respiratory tract, skin, and ears. Generic cefpodoxime oral suspension is available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• bleeding problems
• kidney disease
• stomach or intestinal problems (especially colitis)
• other chronic illness
• an unusual or allergic reaction to cefpodoxime, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take cefpodoxime oral suspension by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one; household spoons are not always accurate. You can take cefpodoxime with or without food. If cefpodoxime upsets your stomach it may help to take it with food. Do not take your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with cefpodoxime?

• antacids
• stomach or ulcer drugs such as nizatidine (Axid®), cimetidine (Tagamet®), famotidine (Pepcid®), or ranitidine (Zantac®)
probenecid

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking cefpodoxime?

Tell your prescriber or health care professional if your symptoms do not begin to improve in a few days.

If you get severe or watery diarrhea, do not treat yourself. Call your prescriber or health care professional for advice.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water, will help.

What side effects may I notice from taking cefpodoxime?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• difficulty breathing, wheezing
• nosebleed
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• seizures (convulsions)
• severe or watery diarrhea
• skin rash, hives, or itching
• swelling of the lips, tongue or face
• swollen joints
• unusual weakness or tiredness
• vaginal itching
• vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• constipation, diarrhea, or other stool changes
• dizziness or drowsiness
• dry mouth
• gas or heartburn
• headache
• insomnia
• loss of appetite
• nausea
• nervousness
• stomach pain

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store the dry granules for suspension at room temperature between 15 and 30 degrees C (59 and 86 degrees F). After mixing the suspension store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F); do not freeze. Throw away unused portion after fourteen days.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Wikipedia: Cefpodoxime
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Cefpodoxime
Systematic (IUPAC) name
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-
2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-
8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid
Identifiers
CAS number 82619-04-3
ATC code J01DD13
PubChem 6335986
ChemSpider 4891496
Chemical data
Formula C15H17N5O6S2 
Mol. mass 427.458 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 50%
Protein binding 21% to 29%
Metabolism Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Half life 2 hours
Excretion Renal, unchanged
Therapeutic considerations
Pregnancy cat.

B1(AU) B(US)

Legal status

-only(US)

Routes Oral
 Yes check.svgY(what is this?)  (verify)

Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin and under the name Orelox by Sanofi-Aventis), is an oral third generation cephalosporin. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.

In India, it is sold for children under the trade name of Zefira (Agio Pharmaceuticals Ltd), Cepotuf (Vanguard Therapeutics Pvt Ltd), Pecef (Dr Reddy's) in 50mg & 100mg DT & DS forms (FGP) and for adults as C-Doxim 200, 100DT, 50 DS (Neomed) and Doxicef 200 (Lupin) in 200mg.

In Nigeria its marketed under brand name of Switch 200mg by Alkem Laboratories..

Structural formula of cefpodoxime proxetil



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Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Cefpodoxime" Read more