CGS-9896: Information from Answers.com


CGS-9896
Systematic (IUPAC) name
2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
Identifiers
CAS number	77779-36-3
ATC code	?
PubChem	108030
Chemical data
Formula	C₁₆H₁₀Cl N₃O
Mol. mass	295.7231 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.^[1]

CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.^[2]^[3] It also increases appetite,^[4] and reduces the development of gastrointestinal ulcers following chronic stress.^[5]

References

^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90342-5.
^ Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID 3343593.
^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch Toxicol. 64 (5): 412–3. doi:10.1007/BF01973465. PMID 2206111.
^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2-3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)00020-W.
^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664.

v • d • e Psycholeptics: anxiolytics (N05B)

GABA_A PAMs	Benzodiazepines: Adinazolam • Alprazolam • Bretazenil • Bromazepam • Camazepam • Chlordiazepoxide • Clobazam • Clonazepam • Clorazepate • Clotiazepam • Cloxazolam • Diazepam • Ethyl Loflazepate • Etizolam • Fludiazepam • Halazepam • Imidazenil • Ketazolam • Lorazepam • Medazepam • Nordazepam • Oxazepam • Pinazepam • Prazepam • Tofisopam; Carbamates: Emylcamate • Carisoprodol • Mebutamate • Meprobamate • Phenprobamate • Procymate • Tybamate; Nonbenzodiazepines: Abecarnil • Adipiplon • Alpidem • CGS-9896 • CGS-20625 • ELB-139 • Etifoxine • GBLD-345 • Gedocarnil • ICI-190,622 • L-838,417 • NS-2664 • NS-2710 • Ocinaplon • Pagoclone • Panadiplon • Pipequaline • RWJ-51204 • SB-205,384 • SL-651,498 • TP-003 • TP-13 • TPA-023 • Tracazolate • Y-23684 • ZK-93423; Others: Chlormezanone • Etazolate • Ethanol (Alcohol) • Kavalactones (Kava Kava) • Skullcap • Valerenic Acid (Valerian)

5-HT_1A Agonists	Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • PRX-00023

H₁ Antagonists	Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine

CRF₁ Antagonists	Antalarmin • CP-154,526 • Pexacerfont

NK₂ Antagonists	GR-159,897 • Saredutant

MCH₁ antagonists	ATC-0175 • SNAP-94847

mGluR₂_/₃ Agonists	Eglumegad

mGluR5 NAMs	Fenobam

TSPO agonists	DAA-1097 • DAA-1106 • Emapunil • FGIN-127 • FGIN-143

Others	Benzoctamine • Mephenoxalone • Promoxolane • Trimetozine

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