A graduate of the University of Minnesota, baleful-eyed, prematurely gray Charles Cioffi made his first off-Broadway appearance in William Gibson's A Cry of Players. Cioffi continued as a familiar presence on the off-Broadway scene, finally making his on Broadway bow in 1990's Stand-Up Tragedy. In his film and TV work, Cioffi has most often been seen as an excitable police official or an uptight executive with something to hide (e.g., the sexually deviant "solid citizen" Peter Cable in Klute). His television work has encompassed a number of daytime soap operas, including Another World, Where the Heart Is, Ryan's Hope, and Days of Our Lives (as Ernest Toscano). Charles Cioffi has also been a regular in the prime-time weeklies Assignment: Vienna (1971), Get Christie Love! (1974), and the 1989 revival of Kojak. ~ Hal Erickson, All Movie Guide
He played Lt. Vic Androzzi in Shaft (1971) and Peter Cable in Klute (1971). He has appeared on Frasier, Wings, The X Files, NYPD Blue, Hawaii Five-O, and various other shows, including Days of our Lives, in which he played the short-lived but memorable role of villain Ernesto Toscano. He has also appeared in several productions both on and off Broadway. He has also made an appearance on Law & Order as mob boss Frank Masucci. He has also voiced Chairman Prescott in the Xbox 360 videogame Gears of War 2