A fundamental principle of combination cancer therapy is that different drugs work through different cytotoxic mechanisms. Because they have different dose-limiting adverse effects, they can be given together at full doses.[1]
The term "Induction regimens" refers to a chemotherapy regimen which is used for the initial treatment of a disease.
| Name |
Components |
Example of uses, and other notes |
| ABVD |
Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine |
Hodgkin's lymphoma |
| AC |
Adriamycin (doxorubicin), cyclophosphamide |
Breast cancer |
| BEACOPP |
Bleomycin, etoposide, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone |
Hodgkin's lymphoma |
| BEP |
Bleomycin, etoposide, platinum agent (cisplatin) |
Testicular cancer, germ cell tumors |
| CA |
Cyclophosphamide, Adriamycin (doxorubicin) (same as AC) |
Breast cancer |
| CAF |
Cyclophosphamide, Adriamycin (doxorubicin), fluorouracil (5-FU) |
Breast cancer |
| CAV |
Cyclophosphamide, Adriamycin (doxorubicin), vincristine |
Lung cancer |
| CBV |
Cyclophosphamide, BCNU (carmustine), VP-16 (etoposide) |
Lymphoma |
| ChlVPP/EVA |
Chlorambucil, vincristine (Oncovin), procarbazine, prednisone, etoposide, vinblastine, Adriamycin (doxorubicin) |
Hodgkin's lymphoma |
| CHOP |
Cyclophosphamide, hydroxydoxorubicin (doxorubicin), vincristine (Oncovin), prednisone |
Non-Hodgkin lymphoma |
| CHOP-R or R-CHOP |
CHOP + rituximab |
B cell non-Hodgkin lymphoma |
| COP or CVP |
Cyclophosphamide, Oncovin (vincristine), prednisone |
Non-Hodgkin lymphoma in patients with history of cardiovascular disease |
| CMF |
Cyclophosphamide, methotrexate, fluorouracil (5-FU) |
Breast cancer |
| COPP |
Cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone |
Non-Hodgkin lymphoma |
| EC |
Epirubicin, cyclophosphamide |
Breast cancer |
| ECF |
Epirubicin, cisplatin, fluorouracil (5-FU) |
Gastric cancer and oesophageal cancer |
| EP |
Etoposide, platinum agent (cisplatin) |
Testicular cancer, germ cell tumors |
| FEC |
Fluorouracil (5-FU), epirubicin, cyclophosphamide |
Breast cancer |
| FL (Also known as Mayo) |
Fluorouracil (5-FU), leucovorin (folinic acid) |
Colorectal cancer |
| FOLFOX |
Fluorouracil (5-FU), leucovorin (folinic acid), oxaliplatin |
Colorectal cancer |
| FOLFIRI |
Fluorouracil (5-FU), leucovorin (folinic acid), irinotecan |
Colorectal cancer |
| ICE |
ifosfamide, carboplatin, etoposide (VP-16) |
Aggressive lymphomas, progressive neuroblastoma |
| ICE-R |
ICE + rituximab |
High-risk progressive or recurrent lymphomas |
| m-BACOD |
Methotrexate, bleomycin, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), dexamethasone |
Non-Hodgkin lymphoma |
| MACOP-B |
Methotrexate, leucovorin (folinic acid), Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), prednisone, bleomycin |
Non-Hodgkin lymphoma |
| MOPP |
Mechlorethamine, Oncovin (vincristine), procarbazine, prednisone |
Hodgkin's lymphoma |
| PCV |
Procarbazine, CCNU (lomustine), vincristine |
Brain tumors |
| ProMACE-MOPP |
Methotrexate, Adriamycin (doxorubicin), cyclophosphamide, etoposide + MOPP |
Non-Hodgkin lymphoma |
| ProMACE-CytaBOM |
Prednisone, doxorubicin (adriamycin), cyclophosphamide, etoposide, cytarabine, bleomycin, Oncovin (vincristine), methotrexate, leucovorin |
Non-Hodgkin lymphoma |
| R-FCM |
Rituximab, fludarabine, cyclophosphamide, mitoxantrone |
B cell non-Hodgkin lymphoma |
| Stanford V |
Doxorubicin, mechlorethamine, bleomycin, vinblastine, vincristine, etoposide, prednisone |
Hodgkin's lymphoma |
| Thal/Dex |
Thalidomide, dexamethasone |
Multiple myeloma |
| TIP |
Paclitaxel, ifosfamide, platinum agent cisplatin |
Testicular cancer, germ cell tumors in salvage therapy |
| VAC |
Vincristine, Actinomycin, Cyclophosphamide |
Rhabdomyosarcoma |
| VAD |
Vincristine, Adriamycin (doxorubicin), dexamethasone |
Multiple myeloma |
| VAPEC-B |
Vincristine, Adriamycin (doxorubicin), prednisone, etoposide, cyclophosphamide, bleomycin |
Hodgkin's lymphoma |
| VIP |
Etoposide, ifosfamide, platinum agent cisplatin |
Testicular cancer, germ cell tumors |
