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Most cases of chickenpox run their course within a week without causing lasting harm. However, there is
one long-term consequence of chickenpox that strikes about 20% of the population, particularly people 50 and older. Like all herpes viruses, the varicella-zoster virus never leaves the body after an episode of chickenpox, but lies dormant in the nerve cells, where it may be reactivated years later by disease or age-related weakening of the immune system. The result is shingles (also called herpes zoster), a very painful nerve inflammation, accompanied by a rash, that usually affects the trunk or the face for 10 days or more. Especially in the elderly, pain, called postherpetic neuralgia, may persist at the site of the shingles for months or years. As of 1998, two newer drugs for treatment of shingles are available. Both valacyclovir (Valtrex) and famciclovir (Famvir) stop the replication of herpes zoster when administered within 72 hours of appearance of the rash. The effectiveness of these two drugs in immunocompromised patients has not been established, and Famvir is not recommended for patients under 18 years, as of 1998.
— Beth Kapes




