Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins.[1] It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.[2]
In humans, the chordin peptide is encoded by the CHRD gene.[3]
References
- ^ Pappano WN, Scott IC, Clark TG, Eddy RL, Shows TB, Greenspan DS (September 1998). "Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes". Genomics 52 (2): 236–9. doi:10.1006/geno.1998.5474. PMID 9782094.
- ^ Millet C, Lemaire P, Orsetti B, Guglielmi P, François V (August 2001). "The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities". Mech. Dev. 106 (1-2): 85–96. PMID 11472837.
- ^ Smith M, Herrell S, Lusher M, Lako L, Simpson C, Wiestner A, Skoda R, Ireland M, Strachan T (1999). "Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes". Hum. Genet. 105 (1-2): 104–11. PMID 10480362.
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Cell signaling: TGF beta signaling pathway |
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| TGF beta superfamily of ligands |
TGF beta family ( TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other ( Activin and inhibin, Anti-müllerian hormone, Nodal)
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TGF beta receptors
(Activin, BMP) |
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| Transducers/SMAD |
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| Ligand inhibitors |
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| Coreceptors |
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| Other |
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