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Citicoline
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| Systematic (IUPAC) name | |
| 5'-O-[hydroxy({hydroxy[2-(trimethylammonio)ethoxy] phosphoryl}oxy)phosphoryl]cytidine |
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| Identifiers | |
| CAS number | 987-78-0 33818-15-4 (sodium salt) |
| ATC code | N06BX06 |
| PubChem | 13805 |
| ChemSpider | 16736209 |
| Chemical data | |
| Formula | C14H27N4O11P2+ |
| Mol. mass | 489.332 g/mol |
| SMILES | eMolecules & PubChem |
| Synonyms | Cytidine diphosphate choline |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
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Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) and cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline.
Studies suggest that CDP-choline supplements increase dopamine receptor densities,[1] and suggest that CDP-choline supplementation can ameliorate memory impairment caused by environmental conditions.[2] Preliminary research at Harvard found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder.[3]
It is an ingredient in some energy drinks such as "5-Hour Energy" and is available as an over the counter nutritional supplement.
Cognizin is the consumer brand for Citicoline produced by Kyowa Hakko Bio. Co., Ltd. and marketed as a dietary supplement and food ingredient by Kyowa Hakko U.S.A.
References
- ^ R. Giménez; J. Raïch, and J. Aguilar (1999-11). "Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice.". British Journal of Pharmacology. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1908237. Retrieved 2009-07-17.
- ^ Teather, Lisa A; Wurtman, Richard J. (2004-11-03). "Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats". Learning & Memory. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=548494. Retrieved 2009-07-17.
- ^ "Supplement naturally boosts ageing brain power". Sydney Morning Herald. 2008-02-25. http://www.smh.com.au/cgi-bin/common/popupPrintArticle.pl?path=/articles/2008/02/24/1203788130776.html. Retrieved 2009-07-28.
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Citicoline (aka Citicholine?)Investigational use in stroke. Ferrer Therapeutics (Spain) has marketing right in U.S.& Canada. The supplement is marketed by Takeda in approx 20 countrys. Research sponsered by Intercardia (A subsid of Interneuron) Ref: Google
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