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| Systematic (IUPAC) name | |
|---|---|
| 2-(2-chlorophenyl)- 9-ethyl- 6-methyl- 8-thia- 3,6-diazabicyclo[5.3.0] deca- 2,9,11-trien- 5-one | |
| Identifiers | |
| CAS number | 33671-46-4 |
| ATC code | N05BA21 |
| PubChem | 2811 |
| DrugBank | ? |
| ChemSpider | 2709 |
| Chemical data | |
| Formula | C16H15ClN2OS |
| Mol. mass | 318.8 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Half life | ? |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | Oral |
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Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. The clotiazepam molecule differs from most other benzodiazepines in that the benzene ring has been replaced by a thiophene ring.[1] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.[2]
Clotiazepam is not approved for sale in the United States or Canada.
See also
References
- ^ Niwa T, Shiraga T, Ishii I, Kagayama A, Takagi A (September 2005). "Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs" (PDF). Biol. Pharm. Bull. 28 (9): 1711–6. doi:. PMID 16141545. http://www.jstage.jst.go.jp/article/bpb/28/9/1711/_pdf.
- ^ Nakazawa Y; Kotorii M, Oshima M, Horikawa S, Tachibana H. (October 31, 1975). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.". Psychopharmacologia. 44 (2): 165–71. doi:. PMID 709.
External links
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