n.
A disease affecting the coagulability of the blood.
Coagulopathy
| Medical Dictionary: co·ag·u·lop·a·thy |
| 5min Related Video: Coagulopathy |
| Veterinary Dictionary: coagulopathy |
Any disorder of blood coagulation. See also hemophilia.
- consumption c. — a bleeding tendency due to a reduction in clotting factors caused by their utilization. See also disseminated intravascular coagulation.
- disseminated intravascular c. (DIC) — see disseminated intravascular coagulation.
- hepatic c. — impaired synthesis of most clotting factors, including factors I, II, V, VII, IX and X, as well as other substances involved in the fibrinolytic system, in severe liver disease can cause significant abnormalities in coagulation.
| Wikipedia: Coagulopathy |
| Coagulopathy | |
|---|---|
| Classification and external resources | |
| ICD-10 | D65.-D68. |
| ICD-9 | 286 |
| DiseasesDB | 29158 |
| MeSH | [1] |
Coagulopathy (also called clotting disorder and bleeding disorder) is a defect in the body's mechanism for blood clotting, causing bleeding diathesis.
Contents |
Causes
While there are several possible causes, they generally result in excessive bleeding and a lack of clotting.
Acquired
Acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, Vitamin K deficiency and disseminated intravascular coagulation.
Additionally, the haemotoxic venom from certain species of snakes can cause this condition e.g. Bothrops, rattlesnakes and other species of viper. Viral hemorrhagic fevers include dengue hemorrhagic fever and Dengue Shock Syndrome
Leukemia may also cause coagulopathy.
Autoimmune causes of acquired coagulation disorders
There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors; termed inhibitors of coagulation. The main inhibitor is directed against Factor VIII Another example is antiphospholipid syndrome.
Genetic
Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of Hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy.
Rare examples are Bernard-Soulier syndrome, Wiskott-Aldrich syndrome and Glanzmann's thrombasthenia.
Symptoms
| Symptom | Disorders |
|---|---|
| Petechiae (red spots) |
|
| Purpura and ecchymoses | |
| Blood in stool | |
| Bleeding gingiva (gums) | |
| Prolonged nose bleeds |
|
Complications
Following are some complications of coagulopathies, some of them caused by their treatments:
| Complication | Disorders |
|---|---|
| Soft tissue bleeding, e.g. deep-muscle bleeding, leading to swelling, numbness or pain of a limb. | |
| Joint damage, potentially with severe pain and even destruction of the joint and development of arthritis |
|
| Retinal bleeding |
|
| Transfusion transmitted infection, from blood transfusions that are given as treatment. |
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| Adverse reactions to clotting factor treatment. |
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| Anemia | |
| Exsanguination (bleeding to death) |
|
| Cerebral hemorrhage |
See also
References
- ^ a b c d e Wiskott-Aldrich Syndrome The International Patient Organisation for Primary Immunodeficiencies (IPOPI).
- ^ a b c d e f g h i Disorders of thrombosis and hemostasis: clinical and laboratory practice. Page Rodger L. Bick. Edition 3, illustrated. ISBN: 0397516908, 9780397516902. 446 pages
- ^ a b c Vitamin K Deficiency eMedicine. Author: Pankaj Patel, MD. Coauthor(s): Mageda Mikhail, MD, Assistant Professor. Updated: Dec 18, 2008
- ^ a b c d Hemophilia Complications By Mayo Clinic staff. May 16, 2009
- ^ a b c d Von Willebrand disease --> Complications By Mayo Clinic staff. Feb. 7, 2009
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 | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Coagulopathy". Read more |
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