Coenzyme F420 or 8-hydroxy-5-deazaflavin is a coenzyme involved in redox reactions in methanogens.[1] It is a flavin derivative. The coenzyme is a substrate for coenzyme F420 hydrogenase,[2] 5,10-methylenetetrahydromethanopterin reductase and methylenetetrahydromethanopterin dehydrogenase.[3][4]
See also
References
- ^ Deppenmeier U (2002). "Redox-driven proton translocation in methanogenic Archaea". Cell. Mol. Life Sci. 59 (9): 1513–33. doi:10.1007/s00018-002-8526-3. PMID 12440773.
- ^ Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT (1987). "8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization". Biochemistry. 26: 4219–27. doi:10.1021/bi00388a007. PMID 3663585.
- ^ Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U (2003). "Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure". J. Mol. Biol. 332 (5): 1047–57. doi:10.1016/S0022-2836(03)00949-5. PMID 14499608.
- ^ GD (1991). "Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079: 293–302. PMID 1911853.
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Enzyme cofactors |
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| Active Forms |
vitamins: TPP / ThDP (B 1) · FMN, FAD (B 2) · NAD+, NADH, NADP+, NADPH (B 3) · Coenzyme A (B 5) · PLP / P5P (B 6) · Biotin (B 7) · THFA / H4FA, DHFA / H2FA, MTHF (B 9) · AdoCbl, MeCbl (B 12) · Ascorbic Acid (C) · Phylloquinone (K 1, Menaquinone (K 2) · Coenzyme F420
non-vitamins: ATP · CTP · SAMe · PAPS · GSH · Coenzyme B · Coenzyme M · Coenzyme Q · Heme / Haem (A, B, C, O) · Lipoic Acid · Methanofuran · Molybdopterin · PQQ · THB / BH4 · THMPT / H4MPT
minerals: Ca2+ · Cu2+ · Fe2+, Fe3+ · Mg2+ · Mn2+ · Mo · Ni2+ · Se · Zn2+
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Major families of biochemicals
Saccharides/Carbohydrates/Glycosides · Amino acids/Peptides/Proteins/Glycoproteins · Lipids/Terpenes/Steroids/Carotenoids · Alkaloids/Nucleobases/Nucleic acids · Cofactors/Flavonoids/Polyketides/Tetrapyrroles |
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