Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CFSR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene.[1][2] It is a receptor for a cytokine called colony stimulating factor 1.
Function
The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. The first intron of the CSFR1 gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene, oriented in the opposite direction to the CSFR1 gene.[1]
Clinical significance
Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.[3] Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active.[4]
Interactions
Colony stimulating factor 1 receptor has been shown to interact with FYN,[5] Suppressor of cytokine signaling 1,[6] Grb2[7] and Cbl gene.[8]
See also
References
- ^ a b "Entrez Gene: CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1436.
- ^ Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet. Cell Genet. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- ^ Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA (February 1990). "FMS mutations in myelodysplastic, leukemic, and normal subjects". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1377–80. doi:10.1073/pnas.87.4.1377. PMID 2406720. PMC: 53478. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=2406720.
- ^ Mitrasinovic OM, Grattan A, Robinson CC, Lapustea NB, Poon C, Ryan H, Phong C, Murphy GM (April 2005). "Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system". J. Neurosci. 25 (17): 4442–51. doi:10.1523/JNEUROSCI.0514-05.2005. PMID 15858070.
- ^ Courtneidge, S A; Dhand R, Pilat D, Twamley G M, Waterfield M D, Roussel M F (Mar. 1993). "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor". EMBO J. (ENGLAND) 12 (3): 943-50. ISSN 0261-4189. PMID 7681396.
- ^ Bourette, R P; De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (Jun. 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. (United States) 276 (25): 22133-9. doi:10.1074/jbc.M101878200. ISSN 0021-9258. PMID 11297560.
- ^ Mancini, A; Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T (Sep. 1997). "Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene (ENGLAND) 15 (13): 1565-72. doi:10.1038/sj.onc.1201518. ISSN 0950-9232. PMID 9380408.
- ^ Mancini, Annalisa; Koch Alexandra, Wilms Regina, Tamura Teruko (Apr. 2002). "c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms". J. Biol. Chem. (United States) 277 (17): 14635-40. doi:10.1074/jbc.M109214200. ISSN 0021-9258. PMID 11847211.
Further reading
- Rettenmier CW, Roussel MF, Sherr CJ (1989). "The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand.". J. Cell Sci. Suppl. 9: 27–44. PMID 2978516.
- Stanley ER, Berg KL, Einstein DB, et al. (1997). "Biology and action of colony--stimulating factor-1.". Mol. Reprod. Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
- Gout I, Dhand R, Panayotou G, et al. (1993). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.". Biochem. J. 288 ( Pt 2): 395–405. PMID 1334406.
- Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.". Cytogenet. Cell Genet. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- Boultwood J, Rack K, Kelly S, et al. (1991). "Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6176–80. doi:10.1073/pnas.88.14.6176. PMID 1829836.
- Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ (1991). "Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.". Nature 353 (6342): 361–3. doi:10.1038/353361a0. PMID 1833648.
- Reedijk M, Liu XQ, Pawson T (1990). "Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.". Mol. Cell. Biol. 10 (11): 5601–8. PMID 2172781.
- Ridge SA, Worwood M, Oscier D, et al. (1990). "FMS mutations in myelodysplastic, leukemic, and normal subjects.". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1377–80. doi:10.1073/pnas.87.4.1377. PMID 2406720.
- Sherr CJ, Rettenmier CW, Sacca R, et al. (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.". Cell 41 (3): 665–76. doi:10.1016/S0092-8674(85)80047-7. PMID 2408759.
- Coussens L, Van Beveren C, Smith D, et al. (1986). "Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.". Nature 320 (6059): 277–80. doi:10.1038/320277a0. PMID 2421165.
- Hampe A, Shamoon BM, Gobet M, et al. (1989). "Nucleotide sequence and structural organization of the human FMS proto-oncogene.". Oncogene Res. 4 (1): 9–17. PMID 2524025.
- Visvader J, Verma IM (1989). "Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.". Mol. Cell. Biol. 9 (3): 1336–41. PMID 2524648.
- Roberts WM, Look AT, Roussel MF, Sherr CJ (1988). "Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.". Cell 55 (4): 655–61. doi:10.1016/0092-8674(88)90224-3. PMID 2846185.
- Xu DQ, Guilhot S, Galibert F (1985). "Restriction fragment length polymorphism of the human c-fms gene.". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2862–5. doi:10.1073/pnas.82.9.2862. PMID 2986142.
- Sherr CJ, Rettenmier CW (1987). "The fms gene and the CSF-1 receptor.". Cancer Surv. 5 (2): 221–32. PMID 3022923.
- Le Beau MM, Westbrook CA, Diaz MO, et al. (1986). "Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders.". Science 231 (4741): 984–7. doi:10.1126/science.3484837. PMID 3484837.
- Wheeler EF, Roussel MF, Hampe A, et al. (1986). "The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.". J. Virol. 59 (2): 224–33. PMID 3525854.
- Browning PJ, Bunn HF, Cline A, et al. (1986). ""Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential.". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7800–4. doi:10.1073/pnas.83.20.7800. PMID 3532121.
- Verbeek JS, Roebroek AJ, van den Ouweland AM, et al. (1985). "Human c-fms proto-oncogene: comparative analysis with an abnormal allele.". Mol. Cell. Biol. 5 (2): 422–6. PMID 3974576.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Proteins: clusters of differentiation (see also list of human clusters of differentiation) |
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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Transmembrane receptors: immune receptors |
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| Cytokine receptor |
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Interleukins ( 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27)
CSF receptors (EPO, GM-CSF, G-CSF)
GH · prolactin · Oncostatin M · Leukemia inhibitory factor
common subunits ( Common gamma chain, common beta chain, gp130)
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Other
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| Other endogenous |
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| Exogenous |
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