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This test requires 15-20 mL of blood.

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Cryoglobulin is an abnormal blood protein associated with several diseases.

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The test is done on a person's serum (the yellow liquid part of blood that separates from the cells after the blood clots ).

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people with cryoglobulin to have symptoms during cold weather: blanching, numbness, and pain in their fingers or toes (Raynaud's phenomenon); bleeding into the skin (purpura); and pain in joints (arthralgia).

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