Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10[1] is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (γ-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.[2] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.[3][4] The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines.[5] This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.[6]. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.[7] The Protein Data Bank accession codes for the structures of CXCL10 are 1lv9,1o7y,1o7z and 1o80.
References
- ^ CXCL10 - chemokine (C-X-C motif) ligand 10
- ^ Luster et al. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315: 672-676, 1985. PMID 3925348
- ^ Dufour et al. IFN-gamma-inducible protein 10 (IP-10; CXCL10) -deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J. Immun. 168:, 2002. PMID 11907072
- ^ Angiolillo et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182: 155-162, 1995. PMID 7540647
- ^ O'Donovan et al. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID 10343098
- ^ Booth et al. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry 41:, 2002. PMID 12173928
- ^ Swaminathan et al. Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure 11: 521-32, 2003. PMID 12737818
Further reading
- Farber JM (1997). "Mig and IP-10: CXC chemokines that target lymphocytes.". J. Leukoc. Biol. 61 (3): 246–57. PMID 9060447.
- Neville LF, Mathiak G, Bagasra O (1998). "The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily.". Cytokine Growth Factor Rev. 8 (3): 207–19. doi:10.1016/S1359-6101(97)00015-4. PMID 9462486.
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PDB Gallery |
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1lv9: CXCR3 Binding Chemokine IP-10/CXCL10
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1o7y: CRYSTAL STRUCTURE OF IP-10 M-FORM
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1o7z: CRYSTAL STRUCTURE OF IP-10 T-FORM
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1o80: CRYSTAL STRUCTURE OF IP-10 H-FORM
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