| edit |
| Chemokine (C-X-C motif) receptor 6 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||
| Symbols | CXCR6; BONZO; CD186; STRL33; TYMSTR | |||||||||||||
| External IDs | OMIM: 605163 MGI: 1934582 HomoloGene: 38197 IUPHAR: CXCR6 | |||||||||||||
|
||||||||||||||
| RNA expression pattern | ||||||||||||||
 |
||||||||||||||
 |
||||||||||||||
| More reference expression data | ||||||||||||||
| Orthologs | ||||||||||||||
| Species | Human | Mouse | ||||||||||||
| Entrez | 10663 | 80901 | ||||||||||||
| Ensembl | ENSG00000172215 | ENSMUSG00000048521 | ||||||||||||
| UniProt | O00574 | n/a | ||||||||||||
| RefSeq | NM_006564 (mRNA) | NM_030712 (mRNA) | ||||||||||||
| NP_006555 (protein) | NP_109637 (protein) | |||||||||||||
| Location | Chr 3: 45.96 - 45.96 Mb |
Chr 9: 123.66 - 123.66 Mb |
||||||||||||
| PubMed search | [1] | [2] | ||||||||||||
C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[1][2][3]
CXCR6 has also recently been designated CD186 (cluster of differentiation 186).
References
- ^ Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (Jun 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". J Exp Med 185 (11): 2015-23. PMID 9166430.
- ^ Deng HK, Unutmaz D, KewalRamani VN, Littman DR (Aug 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature 388 (6639): 296-300. doi:. PMID 9230441.
- ^ "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10663.
External links
- "Chemokine Receptors: CXCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2873.
Further reading
- Ruibal-Ares BH, Belmonte L, Baré PC, et al. (2004). "HIV-1 infection and chemokine receptor modulation.". Curr. HIV Res. 2 (1): 39–50. doi:. PMID 15053339.
- Loetscher M, Amara A, Oberlin E, et al. (1998). "TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.". Curr. Biol. 7 (9): 652–60. doi:. PMID 9285716.
- Hoffman TL, Stephens EB, Narayan O, Doms RW (1998). "HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11360–5. doi:. PMID 9736741.
- Schramm B, Penn ML, Speck RF, et al. (2000). "Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.". J. Virol. 74 (1): 184–92. PMID 10590105.
- Tscherning-Casper C, Vödrös D, Menu E, et al. (2000). "Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.". J. Acquir. Immune Defic. Syndr. 24 (1): 1–9. PMID 10877489.
- Ignatius R, Wei Y, Beaulieu S, et al. (2000). "The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells.". AIDS Res. Hum. Retroviruses 16 (11): 1055–9. doi:. PMID 10933620.
- Unutmaz D, Xiang W, Sunshine MJ, et al. (2000). "The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.". J. Immunol. 165 (6): 3284–92. PMID 10975845.
- Matloubian M, David A, Engel S, et al. (2001). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.". Nat. Immunol. 1 (4): 298–304. doi:. PMID 11017100.
- Wilbanks A, Zondlo SC, Murphy K, et al. (2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines.". J. Immunol. 166 (8): 5145–54. PMID 11290797.
- Lee B, Leslie G, Soilleux E, et al. (2001). "cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.". J. Virol. 75 (24): 12028–38. doi:. PMID 11711593.
- Calabresi PA, Yun SH, Allie R, Whartenby KA (2002). "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.". J. Neuroimmunol. 127 (1-2): 96–105. doi:. PMID 12044980.
- Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.". Blood 100 (1): 11–6. doi:. PMID 12070001.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Duggal P, An P, Beaty TH, et al. (2004). "Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.". Genes Immun. 4 (4): 245–50. doi:. PMID 12761559.
- Koprak S, Matheravidathu S, Springer M, et al. (2003). "Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin.". Cell. Immunol. 223 (1): 1–12. doi:. PMID 12914753.
- Shimaoka T, Nakayama T, Fukumoto N, et al. (2004). "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells.". J. Leukoc. Biol. 75 (2): 267–74. doi:. PMID 14634054.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |
This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
