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Cycloleucine

 
Veterinary Dictionary: cycloleucine

An amino acid important in the study of amino acid transport.

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Wikipedia: Cycloleucine
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Cycloleucine[1]
Cycloleucin.svg
IUPAC name
Other names 1-Aminocyclopentanecarboxylic acid
Identifiers
CAS number 52-52-8
PubChem 2901
SMILES
Properties
Molecular formula C6H11NO2
Molar mass 129.16 g/mol
Melting point

320 °C, 593 K, 608 °F

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cycloleucine is a non-proteinogenic amino acid. It could be classified as a cyclic derivate of norleucine, having two hydrogen atoms less. Leading structure is a cyclopentane-ring. The α-carbon atom is not a stereocenter.

Cycloleucine is a non-metabolisable amino acid and is a specific and reversible inhibitor of nucleic acid methylation, and as such is widely used in biochemical experiments.[2]

References

  1. ^ Cycloleucine at Sigma-Aldrich
  2. ^ M Caboche and JP Bachellerie (1977). "RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation". European Journal of Biochemistry 74: 19–29. 



 
 
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Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Cycloleucine" Read more