n.
An antibiotic effective against a wide range of bacteria, used especially in the treatment of tuberculosis and infections of the urinary tract.
cycloserine
Dictionary:
cy·clo·ser·ine (sī'klō-sĕr'ēn)  |
| 5min Related Video: cycloserine |
| Dental Dictionary: cycloserine |
n
trade name: Seromycin Pulvules; drug class: antitubercu-lar; action: inhibits cell wall synthesis, analog of D-alanine; uses: pulmonary tuberculosis.
| Drug Info: Cycloserine |
Brand names: Seromycin®
Chemical formula:
- Español:
- Cicloserina, Cápsula oral
Cycloserine Oral capsule
What is this medicine?
CYCLOSERINE is an antibiotic. It is used to treat tuberculosis. This medicine is also used to treat infections of the urinary tract. It will not work for colds, flu, or other viral infections.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• alcoholism
• anxiety
• depression or other mental illness
• kidney disease
• seizure disorder
• an unusual or allergic reaction to cycloserine, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine early even if you feel better. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What may interact with this medicine?
• alcohol
• ethionamide
• isoniazid, INH
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular check ups. You will need blood work done regularly.
You may need to take vitamin supplements while on this medicine. Talk to your doctor about the foods you eat and the vitamins you take.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• anxiety, confusion, depression, memory problems
• breathing problems
• change in speech
• dizziness, loss of balance
• excessive sweating
• hallucination, loss of contact with reality
• high blood pressure
• seizure
• tingling, pain, or numbness in the hands or feet
• tremor
• trouble walking
• unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• headache
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| WordNet: cycloserine |
Note: click on a word meaning below to see its connections and related words.
The noun has one meaning:
Meaning #1:
an antibiotic that is especially active against the tubercle bacillus
| Wikipedia: Cycloserine |
Not to be confused with Cyclosarin.
 |
|
|
Cycloserine
|
|
| Systematic (IUPAC) name | |
| (R)-4-amino-1,2-oxazolidin-3-one | |
| Identifiers | |
| CAS number | 68-41-7 |
| ATC code | J04AB01 |
| PubChem | 6234 |
| DrugBank | APRD00894 |
| ChemSpider | 5998 |
| Chemical data | |
| Formula | C3H6N2O2 |
| Mol. mass | 102.092 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ~70% to 90% |
| Metabolism | Hepatic |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status | |
| Routes | Oral |
 (what is this?) (verify) |
|
Cycloserine is an antibiotic effective against Mycobacterium tuberculosis. For the treatment of tuberculosis, it is classified as a second line drug, i.e. its use is only considered if one or more first line drugs cannot be used.
Although in principle active against other bacteria as well, cycloserine is not commonly used in the treatment of infections other than tuberculosis.
Mode of action
The terminal two amino acid residues of the murein precursor lipid II consist of D-alanine, which is produced by the enzyme alanine racemase; the two residues are joined by D-alanine ligase. Both enzymes are competitively inhibited by cycloserine.[1]
It is also being trialed for treatment of phobias[2] as well as an adjuvant to conventional treatments for depression, obsessive-compulsive disorder and schizophrenia. It has been experimentally used for treatment of Gaucher's disease.
Recent research suggests that D-cycloserine may be effective in treating chronic pain.[3]
The side effects are mainly central nervous system (CNS) manifestations, i.e. headache, irritability, depression,psychosis convulsions. Co-administration of pyridoxine can reduce the incidence of some of the CNS side effects (e.g. convulsions).
These psychotropic responses are related to D-cycloserine's action as a partial agonist of the neuronal NMDA receptor for glutamate and have been examined in implications with sensory-related fear extinction in the amygdala.[2]
References
- ^ "Cell Envelope.1995". http://www.micro.siu.edu/micr425/425Notes/02-CellEnv.html. Retrieved 2008-11-08.
- ^ a b Davis, Michael; Karyn M. Myers, Kerry J. Ressler and Barbara O. Rothbaum (2005). "Facilitation of Extinction of Conditioned Fear by D-Cycloserine". American Psychological Society 14 (4): 214–219. doi:. http://userwww.service.emory.edu/~kressle/papers/davisetalFacilitationofExtinction2005CurrDirPsycholScience.pdf. Retrieved 2008-07-15.
- ^ "Newly Identified Drug Relieves Suffering". Science Daily. 2007-06-05. http://www.sciencedaily.com/releases/2007/06/070604123715.htm. Retrieved 2008-07-15.
|
||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Learn More
 | Antituberculosis Drugs |
| Antituberculosis Drugs: Interactions |
| Mycobacterial Infections, Atypical: Treatment |
Help us answer these
 | How cycloserine is metabolized? |
Post a question - any question - to the WikiAnswers community:
Copyrights:
 |
 | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved. Read more |
 |
| Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
 |
| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
 |
| WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. Read more |
 |
| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Cycloserine". Read more |
