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Cytochrome P450, family 2, subfamily E, polypeptide 1
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| Identifiers | ||||||||||||||
| Symbols | CYP2E1; CPE1; CYP2E; P450-J; P450C2E | |||||||||||||
| External IDs | OMIM: 124040 MGI: 88607 HomoloGene: 68089 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1571 | 13106 | ||||||||||||
| Ensembl | ENSG00000130649 | ENSMUSG00000025479 | ||||||||||||
| Uniprot | P05181 | Q05421 | ||||||||||||
| Refseq | NM_000773 (mRNA) NP_000764 (protein) |
NM_021282 (mRNA) NP_067257 (protein) |
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| Location | Chr 10: 135.19 - 135.22 Mb | Chr 7: 140.62 - 140.63 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.
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CYP2E1 Ligands
| Substrates | Inhibitors | Inducers |
|---|---|---|
| Often mentioned: [2]
Other:
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Strong: [3]
unspecified: |
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Regulation of CYP2E1
Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transcriptional induction at high levels of ethanol[4]
See also
References
- ^ Where classes of agents are listed, there may be exceptions within the class
- ^ Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
- ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
- ^ Charles S. Lieber. 1999. Microsomal Ethanol-Oxidizing System (MEOS) The First 30 Years (1968-1998)-A Review. Alcoholism: Clinical and Experimental Research 23(6):991-1007
Further reading
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. doi:. PMID 9890157.
- Kessova I, Cederbaum AI (2003). "CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury". Curr. Mol. Med. 3 (6): 509–18. doi:. PMID 14527082.
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